Overall, the results from this study suggest that the underlying mechanisms that contribute to polarity and IPG effects in human CI recipients might be difficult to determine from animal models that do not exhibit the same anatomy, variance in etiology, electrode placement, and duration of deafness as humans.Ĭochlear implant Electrically evoked compound action potential Interphase gap Polarity.Ĭopyright © 2017 Elsevier B.V. This suggests that these two effects might represent somewhat different aspects of neural health, such as differences in site of excitation versus integrative membrane characteristics, for example. A person may perceive auditory hallucinations as coming through their ears, on the surface of their body, in their mind or from anywhere in the space around them. It will include a discussion of how the sensory stimulus is translated into neural impulses, where in the brain that information is processed, how we perceive pitch, and how we know where sound is coming from. To simplify the auditory pathway: 1.) hair cell receptors synapse with a cochlear branch of the vestibulocochlear nerve. The sounds you hear may seem real, but they’re not. This section will provide an overview of the basic anatomy and function of the auditory system. In the medial geniculate body, the third-order neurons form synapses with quaternary neurons that transmit information to the auditory cortex in the temporal lobe, resulting in the conscious recognition of sound. With the exception of one measure in one group of subjects, results showed that polarity and IPG effects were generally not correlated in a systematic or predictable way. Overview What are auditory hallucinations Auditory hallucinations happen when you hear voices or noises that aren’t there. The primary goal of this study was to examine the combined effects of stimulus polarity and IPG within and across subjects to determine whether both measures represent similar underlying mechanisms related to neural health. ![]() In ears with poorer neural survival, these changes in neural responses are generally less apparent with increasing IPG. Specifically, healthy neurons exhibit larger eCAP amplitudes, lower thresholds, and steeper AGF slopes for increasing IPGs. The interphase gap (IPG) has also been shown to relate to neural survival in animal studies. Specifically, large differences in electrically evoked compound action potential (eCAP) amplitudes and amplitude-growth-function (AGF) slopes between polarities might reflect poorer peripheral neural health, whereas more similar eCAP responses between polarities might reflect better neural health. ![]() Modeling studies suggest that differences in neural responses between polarities might reflect underlying neural health.
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